Thalassaemia Intermedia is a clinical term to describe those individuals who do not require regular blood transfusion, despite having both of their beta globin genes not producing or producing insufficient amounts of beta globin chains. Symptoms of beta thalassaemia intermedia include anemia, delayed pubescence, exercise intolerance, leg ulcers and inflammatory arthritis. Iron overload may occur later in life due to increased absorption of iron from the gut and intermittent transfusions.