Ferriprox Deferiprone

DISEASE INFORMATION

 

IRON REMOVAL (CHELATION) IS IMPORTANT FOR PEOPLE WITH THALASSEMIA SYNDROMES WHO RECEIVE REPEATED BLOOD TRANSFUSIONS.

 

Repeated blood transfusions cause extra iron to build up in the body.1

 

The liver is the main site for iron storage. Extra iron can be removed with iron removal therapy (chelation).1,2

 

The iron that builds up in the heart is harder to remove.2

 

IRON LOADS DIFFERENTLY IN EACH ORGAN. SERUM FERRITIN (TOTAL BODY IRON LEVEL) AND THE IRON LEVEL IN THE LIVER ARE NOT RELATED TO THE IRON LEVEL IN THE HEART.2,3

Iron

Heart-related problems are the leading cause of death in thalassemia major patients with inadequate iron chelation.4

 

References:

  • 1. UK Thalassemia Society. Standards for the clinical care of children and adults with thalassemia in the UK. 3rd edition. UK Thalassemia Society; 2016. Editors Yardurnian A, Telfer P, Shah F, et al. Available online at: http://ukts.org/standards/Standards-2016final.pdf
  • 2. Noetzil LJ, et al. Longitudinal analysis of heart and liver iron in thalassemia major. Blood 2008; 112:2973-2978.
  • 3. Pennell DJ, et al. Cardiovascular function and treatment in beta-thalassemia major: A consensus statement from the American Heart Association. Circulation 2013;128:281–308.
  • 4. Modell B, Khan M, Darlison M, et al. Improved survival of thalassemia major in th UK and relation to T2* cardiovascular magnetic resonance. J Cardiovacular Magn Reson2008;10(42): doi:10.1186/1532-429X-10-42.